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del(5q)

Monday 19 March 2007

Interstitial del(5q) or del(5)(q13q33) is the most common structural rearrangement in myelodysplastic syndromes (MDS) (10%) and in acute myeloid leukemias (ANLL). Interstitial del(5q) was first described in refractory anemia.

Isolated deletions of the long arm of chromosome 5, del(5q), are observed in 10% of myelodysplastic syndromes (MDS) and are associated with a more favorable prognosis, although the clinical course varies considerably.

If one or more additional chromosomal aberrations are present, this correlates with a significantly shorter overall survival.

Tumors

- myelodysplastic syndromes (MDS) (10%)
- acute myeloid leukemias (ANLL or AML)
- refractory anemia

Associations

- tetraploidy in myelodysplastic syndrome (18474300).

See also

- 5q- syndrom [del(5q) as the sole karyotypic anomaly]
- myelodysplastic syndromes (MDS) with del(5q) and additional karyotypic anomalies
- acute myeloid leukemias (ANLL) with del(5q) (solely or not)

- tumoral deletions
- Oncobase

References

- Znoyko I, Stuart RK, Ellingham T, Winters J, Wolff DJ, Quigley DI. Tetraploidy and 5q deletion in myelodysplastic syndrome: A case report. Cancer Genet Cytogenet. 2008 May;183(1):64-8. PMID: 18474300

- Evers C, Beier M, Poelitz A, Hildebrandt B, Servan K, Drechsler M, Germing U, Royer HD, Royer-Pokora B. Molecular definition of chromosome arm 5q deletion end points and detection of hidden aberrations in patients with myelodysplastic syndromes and isolated del(5q) using oligonucleotide array CGH. Genes Chromosomes Cancer. 2007 Sep 6; PMID: 17823930