splenic foamy macrophages

Digital slides

 JRC:336 : Niemann-Pick’s disease (Spleen)

Etiology

 mycobacterial infections (#16189163#)

• Mycobacterium tuberculosis (tuberculosis)
• Mycobacterium avium complex infections
  • Mycobacterium kansasii
  • Mycobacterium avium intracellulare infections in AIDS
  • Mycobacterium genavense in AIDS (#8279457#)

 genetic metabolic diseases

• splenic storage diseases
  • Gaucher disease
  • Niemann-Pick disease type B (NPD-B)

 systemic histiocytoses

• Langerhans cell histiocytosis
• Erdheim-Chester disease (#15509691#)
• systemic juvenile xanthogranuloma
• malignant histiocytosis (#7104067#)

 splenic destruction of cells

• immune thrombocytopenia (#4039846#, #4049543#, #6684881#)
• hemolytic anemia due to red cell adenosine deaminase (ADA) overproduction (#4049543#)

 rheumatoid arthritis (RA) treated with gold (#4049543#)

Case records

 Case 12002 : Systemic granulomatosis in Mycobacterium avium intracellulare in combined immune deficiency.

See also

 macrophagic infiltrations

• splenic macrophagic infiltration

References

 Dunn P, Kuo MC, Sun CF. Pseudo-Gaucher cells in mycobacterial infection: a report of two cases. J Clin Pathol. 2005 Oct;58(10):1113-4. PMID: #16189163#

 Maschek H, Georgii A, Schmidt RE, Kirschner P, Böttger EC. Mycobacterium genavense. Autopsy findings in three patients. Am J Clin Pathol. 1994 Jan;101(1):95-9. PMID: #8279457#

 Solis OG, Belmonte AH, Ramaswamy G, et al. Pseudogaucher cells in Mycobacterium avium intracellulare infection in acquired immune deficiency syndrome (AIDS). Am J Clin Pathol 1986;85:233–5. PMID: #3946307#

 Links TP, Karrenbeld A, Steensma JT, et al. Fatal respiratory failure caused by pulmonary infiltration by pseudo-Gaucher cells. Chest 1992;101:265–6. PMID: #1729081#

 Beutler E. Gaucheri’s disease. N Engl J Med 1991;325:1354–60.

 Zidar BL, Hartsock RJ, Lee RE, et al. Pseudo-Gaucher cells in the bone marrow of a patient with Hodgkin’s disease. Am J Clin Pathol 1987;87:533–6.

 Zaino EC, Rossi MB, Pham TD, et al. Gaucher’s cells in thalassemia. Blood 1971;38:457–62.

 Scullin DC, Shelburne JD, Cohen HJ. Pseudo-Gaucher cells in multiple myeloma. Am J Med 1979;67:347–52.

 Carrington PA, Stevens RF, Lendon M. Pseudo-Gaucher cells. J Clin Pathol 1992;45:360.

 Stewart AJ, Jones RD. Pseudo-Gaucher cells in myelodysplasia. J Clin Pathol 1999;52:917–18.