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hepatocytic PAS+ non-glycogenic globules

Monday 12 March 2007

Loacalization

- centrilobular regions (#362805#)

  • non-alpha-1-antitrypsin globules
    • centrilobular sinusoidal dilatation (#362805#)
    • confluent centrilobular necrosis (#362805#)
    • hepatic congestion (#2451899#)

- periportal regions

  • alpha-1-antitrypsin globules

Types

- hepatocytic alpha-1-antitrypsin globules

References

- Reintoft I. Periodic acid Schiff-positive non-glycogenic globules in hepatocytes. Differential diagnostic aspects in screening for alpha-1-antitrypsin globules in an autopsy material. Acta Pathol Microbiol Scand [A]. 1978 Jul;86(4):325-9. PMID: #362805#

- Qizilbash A, Young-Pong O. Alpha 1 antitrypsin liver disease differential diagnosis of PAS-positive, diastase-resistant globules in liver cells. m J Clin Pathol. 1983 Jun;79(6):697-702. PMID: #189389#

- att EC, Koss MN, Young TS, Macauley L, Martin SE. Hepatic hyaline globules associated with passive congestion. Arch Pathol Lab Med. 1988 May;112(5):510-3. PMID: #2451899#

- Pariente EA, Degott C, Martin JP, Feldmann G, Potet F, Benhamou JP. Hepatocytic PAS-positive diastase-resistance inclusions in the absence of alpha-1-antitrypsin deficiency—high prevalence in alcoholic cirrhosis. Am J Clin Pathol. 1981 Sep;76(3):299-302. PMID: #6169273#