Monday 6 October 2003
Rheumatoid arthritis is a chronic inflammatory joint disease with a complex etiology in which environmental factors within a genetically susceptible host maneuver the innate and adaptive arms of the immune system toward recognition of autoantigens.
Rheumatoid arthritis (RA) is the most common systemic autoimmune disease, affecting 1% of the adult population worldwide, with an estimated heritability of 60%.
Zhernakova A, Alizadeh BZ, Bevova M, Leeuwen MA, Coenen MJ, Franke B, Franke L, Posthumus MD, Heel DA, Steege G, Radstake TR, Barrera P, Roep BO, Koeleman BP, Wijmenga C.Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseases.Am J Hum Genet. 2007 Dec;81(6):1284-8. PMID: 17999365