Friday 9 March 2007
The overall mission of oncogenomics is to leverage the power of genome wide high-throughput approaches to improve the outcome of patients with cancers.
Oncogenomics has four primary goals:
Applying high throughput genomics and proteomics to characterize malignancies.
Targeting tumors and cancers: Identification, validation and translation to the clinic.
Systems Biology of tumors: Integration of mathematical modeling and bioinformatics to decipher the complex interactions of DNA copy number, messenger RNA (mRNA), micro RNA (miRNA) and protein with the cancer phenotype.
Public release of data to stimulate collaborative research and maximally utilize high quality data generated by our section and other investigators in the field.
To achieve these goals we are applying DNA microarray-based and other high throughput techniques including:
Gene expression analysis.
Comparative genomic hybridization (CGH)
Small RNA technologies.
Isotope-Coded Affinity Tags (ICAT)
Oncogenomics research has been divided into three distinct, but interrelated projects.
Project 1: Applying High Throughput Genomics and Proteomics to Characterize High Risk Pediatric Solid Tumors.
Project 2: Translational Genomics Targeting High Risk Neuroblastoma.
Project 3: Computational and Systems Biology of Neuroblastoma.
Biotechs > Oncogenomics
Biotechs > Oncogenetics
Kim SY, Hahn WC. Cancer genomics: integrating form and function. Carcinogenesis 2007;28:1387-1392.