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three-dimensional culture

Wednesday 7 March 2007

Three-dimensional culture systems are widely viewed as an innovative tool to model cellular interactions, differentiation, and cell fate during both normal epithelial development and carcinoma progression.

Specific cancer-relevant biological problems can be uniquely explored in 3-D culture systems, including:
1) cell death and survival during lumen formation
2) stem cells and epithelial differentiation
3) apicobasal polarity
4) invasion and metastasis.

See also

- cancer biology
- organotypic models of cancers

References

- The third dimension bridges the gap between cell culture and live tissue. Pampaloni F, Reynaud EG, Stelzer EH. Nat Rev Mol Cell Biol. 2007 Oct;8(10):839-45. PMID: #17684528#

- Life isn’t flat: taking cancer biology to the next dimension. Smalley KS, Lioni M, Herlyn M. In Vitro Cell Dev Biol Anim. 2006 Sep-Oct;42(8-9):242-7. PMID: #17163781#