Wednesday 7 March 2007
Three-dimensional culture systems are widely viewed as an innovative tool to model cellular interactions, differentiation, and cell fate during both normal epithelial development and carcinoma progression.
Specific cancer-relevant biological problems can be uniquely explored in 3-D culture systems, including:
1) cell death and survival during lumen formation
2) stem cells and epithelial differentiation
3) apicobasal polarity
4) invasion and metastasis.
organotypic models of cancers