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Long-Evans Cinnamon rat

Sunday 25 February 2007

Long-Evans Cinnamon (LEC) rats exhibit a genetic defect in ATP7B gene, which is homologous to the human Wilson disease gene, resulting in an inability to mobilize copper from the liver.

References

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- Samuele A, Mangiagalli A, Armentero MT, Fancellu R, Bazzini E, Vairetti M, Ferrigno A, Richelmi P, Nappi G, Blandini F. Oxidative stress and pro-apoptotic conditions in a rodent model of Wilson’s disease. Biochim Biophys Acta. 2005 Sep 25;1741(3):325-30. PMID: #16081251#

- Fuentealba IC, Aburto EM. Animal models of copper-associated liver disease. Comp Hepatol. 2003 Apr 3;2(1):5. PMID: #12769823#

- Cuthbert JA. Wilson’s disease: a new gene and an animal model for an old disease. J Investig Med. 1995 Aug;43(4):323-36. PMID: #7552582#