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PSAP

Tuesday 13 February 2007

Prosaposin is a 511-amino acid glycoprotein which is a precursor for 4 saposins that are designated A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long; has nearly identical placement of cysteine residues, glycosylation sites, and helicoregions; and is flanked by proteolytic cleavage sites.

Proteolytic cleavage of prosaposin at each domain boundary is predicted to give rise to 4 saposin proteins. The PSAP gene can be said to be polycistronic.

Pathology

- germline mutations in

- amplification and overexpression of prosaposin in prostate cancer (prostatic adenocarcinoma) (16080200)

  • prosaposin (PSAP) is a secreted protein expressed in androgen-independent (AI) prostate cancer cells.

References

- Koochekpour S, Zhuang YJ, Beroukhim R, Hsieh CL, Hofer MD, Zhau HE, Hiraiwa M, Pattan DY, Ware JL, Luftig RB, Sandhoff K, Sawyers CL, Pienta KJ, Rubin MA, Vessella RL, Sellers WR, Sartor O. Amplification and overexpression of prosaposin in prostate cancer. Genes Chromosomes Cancer. 2005 Dec;44(4):351-64. PMID: 16080200