Home > A. Molecular pathology > NCOA1

NCOA1

2p23

Sunday 4 February 2007

Pathology

- t(2;2)(q35;p23) creating a PAX3/NCOA1 fusion gene (PAX3 at 2q35 and NCOA1 at 2p23) in alveolar rhabdomyosarcoma (15313887)

- Genetic alterations of SRC1 are rare in prostate cancer. The nuclear protein accumulation of SRC1 seems to be mildly increased in androgen ablation resistant prostate cancers (16894533)

References

- Maki HE, Waltering KK, Wallen MJ, Martikainen PM, Tammela TL, van Weerden WM, Vessella RL, Visakorpi T. Screening of genetic and expression alterations of SRC1 gene in prostate cancer. Prostate. 2006 Sep 15;66(13):1391-8. PMID: 16894533

- Wachtel M, Dettling M, Koscielniak E, Stegmaier S, Treuner J, Simon-Klingenstein K, Buhlmann P, Niggli FK, Schafer BW. Gene expression signatures identify rhabdomyosarcoma subtypes and detect a novel t(2;2)(q35;p23) translocation fusing PAX3 to NCOA1. Cancer Res. 2004 Aug 15;64(16):5539-45. PMID: 15313887