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digestive leiomyosarcoma

Friday 2 February 2007

Definition: Digestive leiomyosarcomas are spindle cell tumors showing smooth muscle differentiation.

Images

- Rectal leiomyosarcoma. More pleomorphic than GIST. Desmin+ Dog1-

- intestinal epithelioid leiomyosarcoma / jejunum

Localization

- esophageal leiomyosarcoma
- gastric leiomyosarcoma
- intestinal leiomyosarcoma
- colonic leiomyosarcoma
- rectal leiomyosarcoma

CGH

- CGH losses

Amplification

- 17p13-p11 amplification (16982739)

  • candidate genes: AURKB, SREBF1, MFAP4, and FLJ10847 (16982739)