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spindle cell rhabdomyosarcoma

Tuesday 30 January 2007

spindle-cell rhabdomyosarcoma; SRMS; congenital/infantile spindle cell rhabdomyosarcoma

Definition: The spindle cell subtype of embryonal rhabdomyosarcoma accounts for 3% of all cases. It has a fascicular, spindled, and leiomyomatous growth pattern and can demonstrate notable rhabdomyoblastic differentiation. Some neoplasms show marked collagen deposition and have a nested, storiform growth pattern. This subtype occurs predominantly in the paratesticular region and is rare in the head and neck.

Molecular biology

- Recurrent NCOA2 gene rearrangements in congenital/infantile-type spindle cell rhabdomyosarcoma (SRMS) (23463663)

- MYOD1 mutations in adult-type spindle cell rhabdomyosarcoma (SRMS)

Cytogenetics analysis

- spindle cell rhabdomyosarcoma in adults

See also

- rhabdomyosarcomas

Open references

- Recurrent NCOA2 gene rearrangements in congenital/infantile spindle cell rhabdomyosarcoma. Mosquera JM, Sboner A, Zhang L, Kitabayashi N, Chen CL, Sung YS, Wexler LH, LaQuaglia MP, Edelman M, Sreekantaiah C, Rubin MA, Antonescu CR. Genes Chromosomes Cancer. 2013 Jun;52(6):538-50. doi : 10.1002/gcc.22050
PMID: 23463663

Paywall References

- Mentzel T, Kuhnen C. Spindle cell rhabdomyosarcoma in adults: clinicopathological and immunohistochemical analysis of seven new cases. Virchows Arch. 2006 Nov;449(5):554-60. PMID: 17013628

- Nascimento AF, Fletcher CD. Spindle cell rhabdomyosarcoma in adults. Am J Surg Pathol. 2005 Aug;29(8):1106-13. PMID: 16006807