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t(X;18)(p11;q11)

Tuesday 23 January 2007

A t(X;18)(p11.2;q11.2) is found in almost all synovial sarcomas (8O%).

The translocation t(X ;18)(p11.2 ;q11.2) seems to be specific : it is not found in other spindle cell sarcomas, and very rarely detected in other tumors as malignant fibrous histyocytoma (MFH) or fibrosarcomas.

Molecular biology

- SYT at 18q11.2 and SSX1, SSX2, SSX4 at Xp11.2

  • SYT/SSX1 fusion gene
  • SYT/SSX2 fusion gene
  • SYT/SSX4 fusion gene

Tumors

- synovial sarcoma

See also

- Oncobase

  • tumoral translocations

References

- Translocations involving the X chromosome in solid tumors : presentation of two sarcomas with t(X ;18)(q13,p11). Limon J, Dal Cin P, Sandberg AA. Cancer Genet Cytogenet 1986; 23: 87-91.