pseudo-Gaucher cell

Pseudo-Gaucher cells are histiocytes with cytoplasm containing needle-like inclusions, resembling Gaucher’s cells.

Etiology (exemples)

 chronic myeloid leukaemia (CML)
 thalassaemia (#4328400#)
 multiple myeloma (#380339#)
 acute lymphoblastic leukaemia
 Hodgkin lymphoma (#3103422#)
 non-Hodgkin lymphoma
 myelodysplasia and myelodysplastic syndromes (#10711256#)

 mycobacterioses(#16189163#)

• pulmonary tuberculosis (#1729081#)
• atypical mycobacterioses (#3946307#, (#16189163#)
  • Mycobacterium kansasii in alcoholism (#16189163#)
  • Mycobacterium avium intracellulare (MAI) in AIDS (#3946307#, #16189163#)

See also

 foamy macrophages (foamy histiocytes)

• splenic foamy macrophages

References

 Dunn P, Kuo MC, Sun CF. Pseudo-Gaucher cells in mycobacterial infection: a report of two cases. J Clin Pathol. 2005 Oct;58(10):1113-4. PMID: #16189163#

 Solis OG, Belmonte AH, Ramaswamy G, et al. Pseudogaucher cells in Mycobacterium avium intracellulare infection in acquired immune deficiency syndrome (AIDS). Am J Clin Pathol 1986;85:233–5. PMID: #3946307#

 Links TP, Karrenbeld A, Steensma JT, et al. Fatal respiratory failure caused by pulmonary infiltration by pseudo-Gaucher cells. Chest 1992;101:265–6. PMID: #1729081#

 Beutler E. Gaucheri’s disease. N Engl J Med 1991;325:1354–60.

 Zidar BL, Hartsock RJ, Lee RE, et al. Pseudo-Gaucher cells in the bone marrow of a patient with Hodgkin’s disease. Am J Clin Pathol 1987;87:533–6.

 Zaino EC, Rossi MB, Pham TD, et al. Gaucher’s cells in thalassemia. Blood 1971;38:457–62.

 Scullin DC, Shelburne JD, Cohen HJ. Pseudo-Gaucher cells in multiple myeloma. Am J Med 1979;67:347–52.

 Carrington PA, Stevens RF, Lendon M. Pseudo-Gaucher cells. J Clin Pathol 1992;45:360.

 Stewart AJ, Jones RD. Pseudo-Gaucher cells in myelodysplasia. J Clin Pathol 1999;52:917–18.