Humpath.com - Human pathology

Home > A. Molecular pathology > IL23R

IL23R

MIM.607562 1p32.1-p31.2

Tuesday 26 December 2006

IL23 is a heterodimeric cytokine consisting of p19 (IL23A) (MIM.605580) and p40 (IL12B) (MIM.161561) subunits.

The p40 subunit also interacts with p35 (IL12A) (MIM.161560) to form IL12.

IL23, like IL12, binds to IL12RB1 (MIM.601604), but only IL12 binds to IL12RB2 (MIM.601642).

IL23R does not interact with IL12, but pairs with IL12RB1 to confer IL23 responsiveness on cells expressing both subunits.

Pathology

- IL23R variants in

See also

- IBDs susceptibility

References

- Cargill M, Schrodi SJ, Chang M, Garcia VE, Brandon R, Callis KP, Matsunami N, Ardlie KG, Civello D, Catanese JJ, Leong DU, Panko JM, McAllister LB, Hansen CB, Papenfuss J, Prescott SM, White TJ, Leppert MF, Krueger GG, Begovich AB. A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am J Hum Genet. 2007 Feb;80(2):273-90. PMID: 17236132

- Duerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS, Daly MJ, Steinhart AH, Abraham C, Regueiro M, Griffiths A, Dassopoulos T, Bitton A, Yang H, Targan S, Datta LW, Kistner EO, Schumm LP, Lee AT, Gregersen PK, Barmada MM, Rotter JI, Nicolae DL, Cho JH. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science. 2006 Dec 1;314(5804):1461-3. PMID: 17068223