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splenomegaly

Tuesday 12 December 2006

WKP

Definition: Splenomegaly is an enlargement of the spleen. The spleen usually lies in the left upper quadrant (LUQ) of the human abdomen.

Images

- Massive splenomegaly (4.1 kg) in a patient with primitive myelofibrosis (PMF). Classic intrasinusoidal EMH & atypical megakaryocytic proliferation.

Etiology

Increased function
- removal of defective RBCs
- immune hyperplasia

- extramedullary hematopoiesis

Abnormal blood flow
- cirrhosis
-  vascular anomalies
- hepatic infections

Metabolic diseases
Benign and malignant cellualr infiltrations

See also

- spleen

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