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blood proteome

Saturday 25 November 2006

The low-molecular-weight range of the circulatory proteome is termed the ’peptidome’, and could be a rich source of cancer-specific diagnostic information.

It is a ’recording’ of the cellular and extracellular enzymatic events that take place at the level of the cancer-tissue microenvironment. This new information archive seems to mainly exist in vivo, bound to high-abundance proteins such as albumin.

References

- Petricoin EF, Belluco C, Araujo RP, Liotta LA. The blood peptidome: a higher dimesion of information content for cancer biomarker discovery. Nat Rev Cancer. 2006 Dec;6(12):961-7. PMID: 17093504