Humpath.com - Human pathology

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• tuberous tumors

  10 January

  Etiology
  tuber : digital fibrokeratoma
  tuberous tumors tuberous dermal melanocytic naevus
  See also
  cutaneous tumors

• digital fibrokeratoma

  10 January

  tuber ; Koenen tumor ; acquired digital fibrokeratoma WKP PO
  Synopsis
  tuber : pedunculated to dome shaped nodule on acral skin
  polypoid lesion
  hyperplastic epidermis
  variably acanthotic epidermis with hyperkeratosis / hyperkeratotic orthokeratosis
  dermal anomalies : dense collagen fibers and variable amounts of mature fibroblasts, small blood vessels and elastic tissue
  thickened collagen in dermis is oriented predominantly in the vertical (...)

• cathepsin-K

  7 January

  CTSK WKP PO
  Definition : Cathepsin K, abbreviated CTSK, is an enzyme that in humans is encoded by the CTSK gene. The protein encoded by this gene is a lysosomal cysteine protease involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is expressed predominantly in osteoclasts.
  Pathology
  Germline mutations cause sclerosing osteochondrodysplasia pycnodysostosis, a rare autosomal recessive skeletal dysplasia characterized by (...)

• high-grade oncocytic tumour

  7 January

  HOT ; eosinophilic vacuolated tumor (EVT)
  Images
  https://twitter.com/gcai1978/status/1346915046186770439
  Synopsis
  morphology : pleomorphic cells
  IHC : CD117+, CK7 only rare cells, cathepsin-K +
  Often TSC/MTOR mutations
  Associations
  tuberous sclerosis complex / TSC (#31002177#)
  Differential diagnosis
  HOT should be considered as an emerging renal entity because it does not meet the diagnostic criteria for other recognized eosinophilic renal tumors, such as oncocytoma, (...)

• villonodular tenosynovitis

  19 December 2020

  Tenosynovial giant cell tumour, diffuse type PO
  Synopsis
  diffuse expansive sheets of cells with infiltrative borders and variable cellularity;
  tumor margins are more cellular
  hyperplastic synovium with papillary projections composed of foamy histiocytes and hemosiderin containing macrophages
  large clefts, pseudoglandular or alveolar spaces lined by synovial cells, osteoclast-like multinucleated (10 - 70 nuclei) giant cells, epithelioid cells
  abundant collagen may be present, (...)

• vulvar condyloma acuminatum

  16 December 2020

  Diagnostic differential
  vestibular papillomatois

• vestibular papillomatois

  16 December 2020

  hymenal tag
  Differential diagnosis
  condyloma acuminatum

• lipid-rich cells

  14 December 2020

  Images
  Lipid-rich (with lipoblast like cells) urothelial carcinoma https://twitter.com/FSiadat/status/1338128038471462913

• lipid-rich urothelial carcinoma

  14 December 2020

  Lipid-rich (with lipoblast like cells) urothelial carcinoma.
  Images
  Lipid-rich (with lipoblast like cells) urothelial carcinoma https://twitter.com/FSiadat/status/1338128038471462913
  See also
  lipid-rich cells

• cellular infiltration of the synovium

  9 December 2020

  Types
  inflammatory infiltration of the synovium lymphocytic infiltration of the synovium histiocytic infiltration of the synovium granulomatous infiltration of the synovium
  tumoral infiltration of the synovium
  See also
  cellular infiltration
  synovium

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