Human pathology

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sinonasal NK/T-cell lymphomas

Sinonasal natural killer (NK)/T-cell lymphomas are common in Asia and areas of South and Central America but are rarely seen in North America and Europe.

Sinonasal NK/T-cell lymphomas in the United States most often occur in ethnic groups from areas of reported high frequency (Asia, Central and South America), although less commonly than in endemic populations, and are otherwise similar phenotypically.

Synopsis

- necrosis
- angiodestructive pattern

Immunochemistry

- CD3+
- TIA-1+
- granzyme B+

  • perforin +/-
  • CD56 (66%)
  • CD8 (20%)
  • EBV EBER-ISH (100%)
  • TCR-gamma gene rearrangement (7%)
  • CD16-
  • CD57-

See also

- sinonasal lymphomas

References

- Gaal K, Sun NC, Hernandez AM, Arber DA. Sinonasal NK/T-cell lymphomas in the United States. Am J Surg Pathol. 2000 Nov;24(11):1511-7. PMID: 11075852

- Cuadra-Garcia I, Proulx GM, Wu CL, Wang CC, Pilch BZ, Harris NL, Ferry JA. Sinonasal lymphoma: a clinicopathologic analysis of 58 cases from the Massachusetts General Hospital. Am J Surg Pathol. 1999 Nov;23(11):1356-69. PMID: 10555004

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