secretory carcinoma of the breast
SCA
Secretory carcinomas are distinguished from infiltrating ductal carcinomas of the breast by their characteristic histomorphology and more favorable prognosis and by the expression of a chimeric tyrosine kinase that is encoded by the ETV6/NTRK3 fusion gene.
Etiology
ETV6/NTRK3 fusion gene by translocation t(12;15)(p13;q25)
References
Diallo R, Schaefer KL, Bankfalvi A, Decker T, Ruhnke M, Wulfing P, Jackisch C, Luttges J, Sorensen PH, Singh M, Poremba C. Secretory carcinoma of the breast: a distinct variant of invasive ductal carcinoma assessed by comparative genomic hybridization and immunohistochemistry. Hum Pathol. 2003 Dec;34(12):1299-305. PMID: 14691916