Human pathology

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sacrococcygeal teratoma

Sacrococcygeal teratoma (SCT) is the most common tumor of the newborn with an incidence of 1 in 35,000 to 40,000 live births. In the newborn, the sacrococcygeal site is located at the base of the tailbone (coccyx), is the most common location of teratomas in newborns.

Cytogenetics

- constitutional partial monosomy 7q (14663834)
- constitutional trisomy 2p (14663834)

- constitutional t(12;15)(q13;q25) pat (12165446)

Predisposition

- Currarino syndrome

References

- Sebire NJ, Fowler D, Ramsay AD. Sacrococcygeal tumors in infancy and childhood; a retrospective histopathological review of 85 cases. Fetal Pediatr Pathol. 2004 Sep-Dec;23(5-6):295-303. PMID: 16137166

- Heerema-McKenney A, Harrison MR, Bratton B, Farrell J, Zaloudek C. Congenital teratoma: a clinicopathologic study of 22 fetal and neonatal tumors. Am J Surg Pathol. 2005 Jan;29(1):29-38. PMID: 15613854

- Heifetz SA, Cushing B, Giller R, Shuster JJ, Stolar CJ, Vinocur CD, Hawkins EP. Immature teratomas in children: pathologic considerations: a report from the combined Pediatric Oncology Group/Children’s Cancer Group. Am J Surg Pathol. 1998 Sep;22(9):1115-24. PMID: 9737245