rheumatoid arthritis
Rheumatoid arthritis (RA) is the most common systemic autoimmune disease, affecting 1% of the adult population worldwide, with an estimated heritability of 60%.
Susceptibility loci
HLA-DRB1
I kappa BL (MHC class III region) (12509789)
missense single-nucleotide polymorphism in PTPN22 gene encoding a protein tyrosine phosphatase (15208781)
4q27 (17999365)
Reviews
Weyand CM, Goronzy JJ. Stem cell aging and autoimmunity in rheumatoid arthritis. Trends Mol Med. 2004 Sep;10(9):426-33. PMID: 15350894
References
Zhernakova A, Alizadeh BZ, Bevova M, Leeuwen MA, Coenen MJ, Franke B, Franke L, Posthumus MD, Heel DA, Steege G, Radstake TR, Barrera P, Roep BO, Koeleman BP, Wijmenga C.Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseases.Am J Hum Genet. 2007 Dec;81(6):1284-8. PMID: 17999365