prostatic mucin-producing urothelial-type adenocarcinoma
Prostatic urothelial-type adenocarcinoma arises through a process of glandular metaplasia of the prostatic urethral urothelium and subsequent in situ adenocarcinoma sometimes associated with villous adenoma.
These prostatic adenocarcinomas are analogous to nonurachal adenocarcinomas arising in the bladder from cystitis glandularis.
Prostatic urothelial-type adenocarcinoma is a rare aggressive cancer arising in the prostate.
Synopsis
glandular metaplasia of the prostatic urethra
contiguous transition to adenocarcinoma
dissection of the stroma by mucin pools (100%)
villous features (47%)
necrosis (13.3%)
signet ring cells (20%)
perineural invasion (6.7%)
focal squamous differentiation (6.7%)
granulomatous inflammatory response (6.7%)
Immunohistochemical stains
prostate specific antigen -
prostate specific acid phosphatase -
CDX2 -
beta-catenin -
high molecular weight cytokeratin + (100%)
CK7
CK20 (83.3%)
Differential diagnosis
conventional prostatic mucinous adenocarcinoma
secondary infiltration from a colonic or bladder adenocarcinoma
References
Osunkoya AO, Epstein JI. Primary mucin-producing urothelial-type adenocarcinoma of prostate: report of 15 cases. Am J Surg Pathol. 2007 Sep;31(9):1323-9. PMID: 17721186