phosphoinositides
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Phosphoinositides (PIs) play an essential role in diverse cellular functions. Their intracellular level is strictly regulated by specific phosphoinositides kinases, phosphoinositides phosphatases and phosphoinositides phospholipases.
Members
3-phosphoinositide
Pathology
phosphoinositide signaling diseases
- PTEN-associated diseases
- Src homology 2-containing inositol-5-phosphatase phosphatases in acute myeloid leukemia or diabetes
- myotubularin family members in genetic diseases
- OCRL1 in Lowe syndrome
Features
phosphoinositides signaling pathways
References
Downes CP, Gray A, Lucocq JM. Probing phosphoinositide functions in signaling and membrane trafficking. Trends Cell Biol. 2005 May;15(5):259-68. PMID: 15866030
Jones DR, Divecha N. Linking lipids to chromatin. Curr Opin Genet Dev. 2004 Apr;14(2):196-202. PMID: 15196467
Pendaries C, Tronchere H, Plantavid M, Payrastre B. Phosphoinositide signaling disorders in human diseases. FEBS Lett. 2003 Jul 3;546(1):25-31. PMID: 12829232