pediatric gliomas
Image Gallery
Subtypes
ganglioglioma
- 3q LOH
- 9p LOH
astrocytoma
subependymal giant cell astrocytoma
- 16p LOH
- 21q LOH
High-grade gliomas
4q LOH (54%)
6q LOH (46%)
9p LOH (38%)
10q LOH (38%)
11p LOH (38%)
12 LOH (38%)
13q LOH (69%)
14q LOH (54%)
17 LOH (38%)
18p LOH (46%)
19q LOH (38%)
Gene amplifications in glioblastoma multiforme
amplification of epidermal growth factor receptor (EGFR)
amplification of PDGFRA coding for platelet-derived growth factor receptor alpha (PDGFRalpha)
References
Wong KK, Tsang YT, Chang YM, Su J, Di Francesco AM, Meco D, Riccardi R, Perlaky L, Dauser RC, Adesina A, Bhattacharjee M, Chintagumpala M, Lau CC. Genome-wide allelic imbalance analysis of pediatric gliomas by single nucleotide polymorphic allele array. Cancer Res. 2006 Dec 1;66(23):11172-8. PMID: 17145861