parathyroid adenoma
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Cytogenetics
t(4; 13)(q21;q14) (17455879)
CGH
chromosomal gains
- 9p22-24 gain (43%)
- 9q34 gain (43%).
- Xq26 gain (43%)
- 4q21-28 gain (29%)
- 8p22-23 (29%)
- 16p gain (11%) (9589690)
- 19p gain (9%) (9589690)
chromosomal losses
- 11p loss (26%) (9589690)
- 11q loss (34%) (9589690)
- whole chromosome 11 loss (14%)
- 20q12-13 loss (14%)
- 1p loss (9589690)
- 1q loss (9589690)
- 6q loss (9589690)
- 9p loss (9589690)
- 9q loss (9589690)
- 13q loss (9589690)
- 15q loss (9589690)
Tumoral loci
9p22-24
9q34
Xq26
4q21-28
8p22-23
Genomic amplification
not observed
Gene rearrangement
gene rearrangement and overexpression of the PRAD1/cyclin D1 oncogene
LOH
11q13 LOH (24%)
References
Sammarelli G, Zannoni M, Bonomini S, Delsignore R, Rizzoli V, Sianesi M, Caramatti C. A translocation t(4; 13)(q21;q14) as single clonal chromosomal abnormality in a parathyroid adenoma. Tumori. 2007 Jan-Feb;93(1):97-9. PMID: 17455879
Garcia JL, Tardio JC, Gutierrez NC, Gonzalez MB, Polo JR, Hernandez JM, Menarguez J. Chromosomal imbalances identified by comparative genomic hybridization in sporadic parathyroid adenomas. Eur J Endocrinol. 2002 Feb;146(2):209-13. PMID: 11834430
Agarwal SK, Schrock E, Kester MB, Burns AL, Heffess CS, Ried T, Marx SJ. Comparative genomic hybridization analysis of human parathyroid tumors. Cancer Genet Cytogenet. 1998 Oct 1;106(1):30-6. PMID: 9772906
Palanisamy N, Imanishi Y, Rao PH, Tahara H, Chaganti RS, Arnold A. Novel chromosomal abnormalities identified by comparative genomic hybridization in parathyroid adenomas. J Clin Endocrinol Metab. 1998 May;83(5):1766-70. PMID: 9589690
Cryns VL, Yi SM, Tahara H, Gaz RD, Arnold A. Frequent loss of chromosome arm 1p DNA in parathyroid adenomas. Genes Chromosomes Cancer. 1995 May;13(1):9-17. PMID: 7541648