pancreatic acinar cell carcinoma
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Differential diagnosis
pancreatic endocrine tumors
solid-pseudopapillary tumors
pancreatoblastoma
ductal adenocarcinoma
acinar cell adenoma
focal acinar cell transformation
microglandular carcinoma
Variants
mixed acinar-endocrine carcinoma of the pancreas (15290275)
Molecular biology
frequent allelic loss on chromosome 11p (50%)
alterations in the APC/beta-catenin pathway (23.5%)
Allelotype: 11072247
| 1p36.31 | 4q26-31.1 | 17p13 | 11q | 13q | 15q15-22.1 | 3q | 6q | 8q | 18q | 21q |
| >70% | >70% | >70% | 60%-70% | 60%-70% | 60%-70% | 50%-60% | 50%-60% | 50%-60% | 50%-60% | 50%-60% |
CGH (comparative genomic hybridization): 10862035
| gains | 1q42 | 12p11.2 | Xq12-21 |
| losses | 16p13.2-p13.1 | 16q23 |
See also