Human pathology

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obstructive renal dysplasia

Obstructive multicystic renal dysplasia

Etiology

- anatomical or functional obstruction of congenital lower urinary tract

  • unilateral obstruction
    • unilateral obstruction of pelviureteral junction
    • ureteral implantation anomaly
    • ureteral atresia

Synopsis

- Renal dysplasia lesions

  • cysts formation
  • primary ductules
    • immature dysplastic tubulules surrounded by condensed mesenchyme
    • basement membrane may be thick and eosinophilic
  • immature glomeruli
  • immature tubules
  • metaplastic cartilage foci (islands of immature cartilage)

- association with hydronephrosis and/or hydronephrosis
- dilated and tortuous ureters

Case records

- Case 10041: Ureteral duplication with two blind ureteres and vesical agenesis. Severe caudal regression syndrome with sirenomelia. 19 weeks.