neutrophils
Motility
Morphologic polarity is necessary for the motility of mammalian cells. In leukocytes responding to a chemoattractant, this polarity is regulated by activities of small Rho guanosine triphosphatases (Rho GTPases) and the phosphoinositide 3-kinases (PI3Ks).
Moreover, in neutrophils, lipid products of PI3Ks appear to regulate activation of Rho GTPases, are required for cell motility and accumulate asymmetrically to the plasma membrane at the leading edge of polarized cells.
By spatially regulating Rho GTPases and organizing the leading edge of the cell, PI3Ks and their lipid products could play pivotal roles not only in establishing leukocyte polarity but also as compass molecules that tell the cell where to crawl.
Pathology
neutrophilic infiltration
neutrophilic deficiency
neutrophilic proliferations
neutrophilic disorders
See also
granulocytes diapedesis
neutrophil phagocytosis
neutrophil differentatiation
neutrophil development
polymophonuclear cells
Videos
Neutrophils going to the site of infection
chemotaxis of meutrophils
References
Hallett MB, Dewitt S. Ironing out the wrinkles of neutrophil phagocytosis. Trends Cell Biol. 2007 Mar 9; PMID: 17350842
Rickert P, Weiner OD, Wang F, Bourne HR, Servant G. Leukocytes navigate by compass: roles of PI3Kgamma and its lipid products. Trends Cell Biol. 2000 Nov;10(11):466-73. PMID: 11050418