mismatch repair cancer syndrome
MIM.276300
Mismatch repair cancer syndrome (MRCS) is caused by homozygous or compound heterozygous mutations in the mismatch repair (MMR) genes MLH1 (MIM.120436), MSH2 (MIM.609309), MSH6 (MIM.600678), or PMS2 (MIM.600259).
Tumor predisposition
ependymoma
glioblastoma
oligodendroglioma
neuroblastoma
astrocytoma
medulloblastoma
basal cell carcinoma
colorectal adenocarcinoma
leukemia
lymphoma
See also
MMR genes
hereditary nonpolyposis colorectal cancer (HNPCCs)