Human pathology

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mediastinal desmoid fibromatosis

mediastinal aggressive fibromatosis

Desmoid tumor of the anterior or posterior mediastinum is very rare. Desmoid tumors grow infiltratively and the recurrence rate after operation is high.

Localization

- mostly, posterior mediastinum (16285595, 15143411)
- possible, anterior mediastinum (8188925)
- possible invasion of the great vessels (12467833)

Synopsis

* proliferation of spindle shape cells with collagen fibers * no cytologic atypia * no mitotic figures * tumor cells positive for alpha smooth muscle actin-positive, vimentin-positive and negative for CD34

See also

- desmoid fibromatosis

References

- Cardoso PF, da Silva LC, Bonamigo TP, Geyer G. Intrathoracic desmoid tumor with invasion of the great vessels. Eur J Cardiothorac Surg. 2002 Dec;22(6):1017-9. PMID: 12467833

- Kocak Z, Adli M, Erdir O, Erekul S, Cakmak A. Intrathoracic desmoid tumor of the posterior mediastinum with transdiaphragmatic extension. Report of a case. Tumori. 2000 Nov-Dec;86(6):489-91. PMID: 11218194

- Hoeffel C, Floquet J, Regent D, Chen YB, Hoeffel JC. Periesophageal mediastinal fibromatosis. Abdom Imaging. 2000 May-Jun;25(3):235-8. PMID: 10823440

- Dosios TJ, Angouras DC, Floros DG. Primary desmoid tumor of the posterior mediastinum. Ann Thorac Surg. 1998 Dec;66(6):2098-9. PMID: 9930504