loss of heterozygosity (LOH)
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Definition: In cells that carry a mutated allele of a tumour-suppressor gene, the gene becomes fully inactivated when the cell loses a large part of the chromosome carrying the wild-type allele. Regions with high frequency of LOH are believed to harbour tumour-suppressor genes.
Types
fractional LOH (fractional allelic loss)
See also
LOH study
LOH regions
LOH database in human tumors
allelotyping
laser capture microdissection and LOH
clustering of minimal deleted regions
References
Tomlinson IP, Lambros MB, Roylance RR. Loss of heterozygosity analysis: practically and conceptually flawed?
Genes Chromosomes Cancer. 2002 Aug;34(4):349-53. PMID: 12112523
Thiagalingam S, Foy RL, Cheng KH, Lee HJ, Thiagalingam A, Ponte JF. Loss of heterozygosity as a predictor to map tumor suppressor genes in cancer: molecular basis of its occurrence. Curr Opin Oncol. 2002 Jan;14(1):65-72. PMID: 11790983