Children with peripheral neuroblastic tumors present with localized resectable disease without metastases in 20% to 30% of the occurrences (International Neuroblastoma Staging System [INSS] stages 1 and 2).
The outcome of these patients is good, with overall survival (OS) ranging from 80% to 100%.
The relapse-free survival (RFS) of patients with INSS stage 1 disease treated by surgery alone is close to 100%.
However, this is not true for patients with INSS stage 2 disease. Factors such as abdominal localization, tumor rupture during surgery, regional lymph node involvement, unfavorable histopathology, or MYCN amplification have been regarded as indicators of relapse.
See also
neuroblastoma
References
Prognostic Value of International Neuroblastoma Pathology Classification in Localized Resectable Peripheral Neuroblastic Tumors: A Histopathologic Study of Localized Neuroblastoma European Study Group 94.01 Trial and Protocol
Samuel Navarro, Gabriele Amann, Klaus Beiske, Catherine J. Cullinane, Emanuele S.G. d’Amore, Claudio Gambini, Véronique Mosseri, Bruno De Bernardi, Jean Michon, Michel Peuchmaur. Journal of Clinical Oncology, Vol 24, No 4 (February 1), 2006: pp. 695-699 (Free)