lipid-laden macrophages
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spumous macrophages, foamy macrophages, foam cells
Definition: Macrophages that are laden with lipid (predominantly cholesterol), and that have differentiated from circulating monocytes.
Etiology (Exemples)
xanthomatous tumors
histiocytoses
- Langerhans cell histiocytosis
- non-Langerhans cell histiocytosis
- juvenile xanthogranunloma
- Erdheim-Chester disease
inherited metabolic diseases
Localization
renal foamy macrophages
- glomerular intracapillary foamy macrophages
- renal tubulary foamy macrophages