intramuscular myxoma
Intramuscular myxoma is a benign soft-tissue tumor that presents as a deeply seated mass confined to skeletal muscle.
Synopsisi
hypocellular, hypovascular regions
cytologically bland stellate and bipolar fibroblasts separated by abundant extracellular myxoid matrix
areas of increased cellularity and vascularity that can lead to a mistaken diagnosis of sarcoma
- The hypercellular regions are not associated with cytologic atypia of the constituent cells, mitotic activity, or necrosis. (9777984)
Cytogenetics
hyperdiploidy
trisomy 18
Differential diagnosis
myxofibrosarcoma
low-grade fibromyxoid sarcoma
myxoid liposarcoma
Prognosis
Surgical excision is virtually always curative. - Recurrence, even after incomplete resection, is exceptional.
References
Nielsen GP, O’Connell JX, Rosenberg AE. Intramuscular myxoma: a clinicopathologic study of 51 cases with emphasis on hypercellular and hypervascular variants. Am J Surg Pathol. 1998 Oct;22(10):1222-7.
PMID: 9777984