Human pathology

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intraductal carcinoma of the oral cavity

Pure in situ form of salivary duct carcinoma.

Synopsis

- crowded and smooth-contoured epithelial units exhibiting a fenestrated or cribriform pattern
- +/- comedonecrosis
- layer of myoepithelial cells demonstrated by immunostaining for p63 and actin, indicating absence of an invasive component.

Prognosis

- good prognosis after local excision

References

- Cheuk W, Miliauskas JR, Chan JK. Intraductal carcinoma of the oral cavity: a case report and a reappraisal of the concept of pure ductal carcinoma in situ in salivary duct carcinoma. Am J Surg Pathol. 2004 Feb;28(2):266-70. PMID: 15043319