Human pathology

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interstitial chromosome 6 deletion

Interstitial deletions of chromosome 6q are a relatively rare finding. Deletions have ranged from the loss of a single band to larger deletions spanning multiple bands. The clinical phenotype varies, but some features commonly seen include cardiac anomalies, hypotonia, facial dysmorphism and mental retardation.

Synopsis

- cardiac anomalies
- hypotonia
- facial dysmorphism
- mental retardation

References

- Zherebtsov MM, Klein RT, Aviv H, Toruner GA, Hanna NN, Brooks SS. Further delineation of interstitial chromosome 6 deletion syndrome and review of the literature. Clin Dysmorphol. 2007 Jul;16(3):135-40. PMID: 17551325