Human pathology

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inhibitors of the proteasome

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Ubiquitin-Proteasome System
proteasomal inhibitors

Examples

- Multiple myeloma cells are unusually sensitive to inhibitors of the proteasome, a cellular organelle that specifically degrades unwanted and misfolded proteins, and proteasome inhibitor drugs have shown promise in patients.

References

- Jiang YH, Beaudet AL. Human disorders of ubiquitination and proteasomal degradation. Curr Opin Pediatr. 2004 Aug;16(4):419-26. PMID: 15273504

- Ciechanover A, Ben-Saadon R. N-terminal ubiquitination: more protein substrates join in. Trends Cell Biol. 2004 Mar;14(3):103-6. PMID: 15055197

Keywords