idiopathic myelofibrosis
chronic idiopathic myelofibrosis
Idiopathic myelofibrosis (IM), is a chronic myeloproliferative disorder (MPD) characterised by marrow fibrosis, extramedullary haematopoiesis and a leuco-erythroblastic picture of the peripheral blood.
Associations
multiple myeloma (7644355)
Cytogenetics
trisomy 1q
del(13q)
del(20q)
trisomy 8
t(6;10) (q27;q11) (11248333)
References
Cox MC, Panetta P, Venditti A, Abruzzese E, Del Poeta G, Cantonetti M, Amadori S. New reciprocal translocation t(6;10) (q27;q11) associated with idiopathic myelofibrosis and eosinophilia. Leuk Res. 2001 Apr;25(4):349-51. PMID: 11248333