Human pathology

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i(12p)

i(12)p, isochromosome 12p

Diseases

- tissue-limited or tissue-specific mosaicism with i(12p) in Pallister-Killian syndrome

Tumors

- mediastinal germ cell tumors

  • with myelodysplastic syndrome

- testicular germ cell tumors (12660824, 8527395)
- intracranial germ cell tumors (12071636, 9870692, 9428355)

- primary choriocarcinoma of the bladder (11912411)
- mediastinal centroblastic lymphoma (10858038)
- acute myeloid leukaemia (8652392)

See also

- i(12)(p10)

References

- Looijenga LH, Zafarana G, Grygalewicz B, Summersgill B, Debiec-Rychter M, Veltman J, Schoenmakers EF, Rodriguez S, Jafer O, Clark J, van Kessel AG, Shipley J, van Gurp RJ, Gillis AJ, Oosterhuis JW. Role of gain of 12p in germ cell tumour development. APMIS. 2003 Jan;111(1):161-71. PMID: 12752258