Human pathology

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homocysteine

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Folate-homocysteine pathway

Pathology

- hyperhomocysteinemia

  • hyperhomocysteinemia is an independent risk factor for cardiovascular disease

- anomalies of homocysteine remethylation: risk of spina bifida

References

- Huhta JC, Hernandez-Robles JA. Homocysteine, folate, and congenital heart defects. Fetal Pediatr Pathol. 2005 Mar-Apr;24(2):71-9. PMID: 16243751

- Ulrey CL, Liu L, Andrews LG, Tollefsbol TO. The impact of metabolism on DNA methylation. Hum Mol Genet. 2005 Apr 15;14 Spec No 1:R139-47. PMID: 15809266

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