giant cell granuloma of the jaws
CGCG, central giant cell granuloma
Central giant cell granuloma (CGCG) of the jaws is a central osteolytic lesion characterized histologically by multinucleated giant cells in a background of ovoid to spindle-shaped mesenchymal cells. Whether CGCG is a reactive lesion or a truly benign neoplasm remains undetermined, and the mechanism determining the onset of the disease remains unknown.
Localization
maxillary
mandible
Expression profiling: 15915104
Gene overexpression
Cyclin D1 protein overexpression (15128059)
See also
giant cell granuloma of the bone
References
Liu B, Yu SF, Li TJ. Multinucleated giant cells in various forms of giant cell containing lesions of the jaws express features of osteoclasts. J Oral Pathol Med. 2003 Jul;32(6):367-75. PMID: 12787044