gastric MALT lymphoma
gastric MZBCL, gastric marginal zone B-cell lymphoma
Approximately 70% of gastric mucosa-associated lymphoid tissue (MALT) lymphomas can be successfully treated with H. pylori eradication.
Cytogenetics
translocation t(11;18)(q21;q21)
- The translocation t(11;18)(q21;q21) characteristic of MALT lymphoma is recognized as a marker for H. pylori independency, but this marker is found in only a half of the MALT lymphomas resistant to H. pylori eradication.
trisomy 3 (17492756#)
Genomic imbalances are associated with H. pylori independency in t(11;18) negative gastric MALT lymphomas. (17492756)
See also
Helicobacter pyloir eradication resistant gastric MALT lymphoma
References
Fukuhara N, Nakamura T, Nakagawa M, Tagawa H, Takeuchi I, Yatabe Y, Morishima Y, Nakamura S, Seto M. Chromosomal imbalances are associated with outcome of Helicobacter pylori eradication in t(11;18)(q21;q21) negative gastric mucosa-associated lymphoid tissue lymphomas. Genes Chromosomes Cancer. 2007 May 10;46(8):784-790 PMID: 17492756