fusion proteins
Image Gallery
balanced translocations
- EWSR1/FLI1 by 22q12 insertion in Chr.11 in ES/PNET
- EWSR1/ERG by 21q21-q22 insertion in 22q12 (15899394) or 22q12 insertion in 21q21-q22 in ES/PNET
- RUNX1/CBFA2T1 (AML1/ETO) in acute myeloid leukemia (AML-M2)
- PML/RARA in acute myeloid leukemia (AML-M3)
- CBFB/MYH1 in acute myeloid leukemia (AML-M4)
Some examples of oncogentic fusion genes
Fusion proteins in sarcomas
| Ewing sarcoma (ES/PNET) | EWS/FLI1 | ||
| congenital fibrosarcoma | ETV6/NTRK3 | ||
| inflammatory myofibroblastic tumor | ALK/TPM3 | ALK/TPM4 | ALK/CLTC |
Fusion proteins in renal tumors
| cellular mesoblastic nephroma | ETV6/NTRK3 |
Fusion proteins in carcinomas
| juvenile renal cell carcinoma | TFE3 | TFEB | ||||
| poorly differentiated carcinoma | BRD4/NUT | |||||
| thyroid carcinomas | PAX8/PPARG1 | |||||
| papillary thyroid carcinoma | RET/PTC1 | RET/PTC2 | RET/PTC3 | RET/PTC8 | RET/PCM1 | RET/RFG8 |
Common fusion protein in different tumors
ETV6/NTRK fusion gene in
- congenital fibrosarcoma|leukemia
- cellular mesoblastic nephroma
ALK/TPM3 fusion gene in
- anaplastic large-cell lymphoma
- inflammatory myofibroblastic tumor
- anaplastic large-cell lymphoma
- inflammatory myofibroblastic tumor
- angiomatoid fibrous histiocytoma (17724745)
- clear cell sarcoma (17000668)|
See also
References
Damm-Welk C, Fuchs U, Wossmann W, Borkhardt A. Targeting oncogenic fusion genes in leukemias and lymphomas by RNA interference. Semin Cancer Biol. 2003 Aug;13(4):283-92. PMID: 14563123
Rabbitts TH, Stocks MR. Chromosomal translocation products engender new intracellular therapeutic technologies. Nat Med. 2003 Apr;9(4):383-6. PMID: 12669051
Mitelman F, Johansson B, Mertens F. Fusion genes and rearranged genes as a linear function of chromosome aberrations in cancer. Nat Genet. 2004 Apr;36(4):331-4. PMID: 15054488
Bohlander SK. Fusion genes in leukemia: an emerging network. Cytogenet Cell Genet. 2000;91(1-4):52-6. PMID: 11173830