Features
farnesyl transferase
farnesyl transferase inhibitors (FTIs)
Therapeutics
FTIs are signal transduction inhibitors that display promising clinical activity against a broad spectrum of malignancies.
References
Meta M, Yang SH, Bergo MO, Fong LG, Young SG. Protein farnesyltransferase inhibitors and progeria. Trends Mol Med. 2006 Oct;12(10):480-7. PMID: 16942914
Karp JE, Lancet JE. Targeting the process of farynesylation for therapy of hematologic malignancies. Curr Mol Med. 2005 Nov;5(7):643-52. PMID: 16305490
Magee T, Seabra MC. Fatty acylation and prenylation of proteins: what’s hot in fat. Curr Opin Cell Biol. 2005 Apr;17(2):190-6. PMID: 15780596
Brunner TB, Hahn SM, Gupta AK, Muschel RJ, McKenna WG, Bernhard EJ. Farnesyltransferase inhibitors: an overview of the results of preclinical and clinical investigations. Cancer Res. 2003 Sep 15;63(18):5656-68. PMID: 14522880
Sebti SM, Der CJ. Opinion: Searching for the elusive targets of farnesyltransferase inhibitors. Nat Rev Cancer. 2003 Dec;3(12):945-51. PMID: 14737124