Human pathology

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deafnesses

deafness

hearing loss, deafness

Types

- DFNAs (deafness, autosomal dominant nonsyndromic sensorineural types)

Etiology

- myosin-associated deafness
- cadherin-associated deafness
- connexin-associated deafness (connexinopathies)

- CRYM mutations (12471561)
- TMIE mutations (transmembrane inner ear expressed gene) (12145746)
- EYA4 mutations (autosomal dominant nonsyndromic sensorineural deafness) (MIM.601316)

References

- Petit C. From deafness genes to hearing mechanisms: harmony and counterpoint. Trends Mol Med. 2006 Feb;12(2):57-64. PMID: 16406841

- Ben-Yosef T, Friedman TB. The genetic bases for syndromic and nonsyndromic deafness among Jews. Trends Mol Med. 2003 Nov;9(11):496-502. PMID: 14604828

- Ahituv N, Avraham KB. Mouse models for human deafness: current tools for new fashions. Trends Mol Med. 2002 Sep;8(9):447-51. PMID: 12223317

- Morton CC. Genetics, genomics and gene discovery in the auditory system. Hum Mol Genet. 2002 May 15;11(10):1229-40. PMID: 12015283

- Rabionet R, Lopez-Bigas N, Arbones ML, Estivill X. Connexin mutations in hearing loss, dermatological and neurological disorders. Trends Mol Med. 2002 May;8(5):205-12. PMID: 12067629

- Steel KP, Bussoli TJ. Deafness genes: expressions of surprise. Trends Genet. 1999 Jun;15(6):207-11. PMID: 10354578

- Kalatzis V, Petit C. The fundamental and medical impacts of recent progress in research on hereditary hearing loss. Hum Mol Genet. 1998;7(10):1589-97. PMID: 9735380