congenital fibrosarcoma
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infantile fibrosarcoma
Localization
soft tissues
digestive congenital fibrosarcoma
- duodenal congenital fibrosarcoma (1185470)
- jejunal congenital fibrosarcoma (12776248)
Cytogenetics
translocation t(12;15)(p13;q25) with ETV6/NTRK3 fusion gene
trisomy 11 (1524466)
trisomy 8
trisomy 17
trisomy 20 (1524466)
Molecular biology
ETV6/NTRK3 fusion gene by translocation t(12;15)(p13;q25)
References
Bourgeois JM, Knezevich SR, Mathers JA, Sorensen PH. Molecular detection of the ETV6-NTRK3 gene fusion differentiates congenital fibrosarcoma from other childhood spindle cell tumors. Am J Surg Pathol. 2000 Jul;24(7):937-46. PMID: 10895816
Argyle JC, Tomlinson GE, Stewart D, Schneider NR. Ultrastructural, immunocytochemical, and cytogenetic characterization of a large congenital fibrosarcoma. Arch Pathol Lab Med. 1992 Sep;116(9):972-5. PMID: 1524466