Human pathology

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chronic neutropenia

Severe chronic neutropenia (SCN) Severe chronic neutropenia (SCN), Kostmann syndrome, Congenital neutropenia

Etiology

- severe congenital neutropenia and cyclic neutropenia (mutations in the neutrophil elastase gene)
- myelokathexis (downregulation of the bcl-x protein)
- glycogen storage disease type 1b
- Chediak-Higashi syndrome
- Shwachman-Diamond syndrome
- dyskeratosis congenita
- Griscelli syndrome
- Barth syndrome
- Wiskott-Aldrich syndrome

- idiopathic neutropeni
- pure white-cell aplasia
- myelodysplasia
- aplastic anemia