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autosomal dominant cerebellar ataxias

ADCAs

See spinocerebellar ataxias (SCAs)

Types

- autosomal dominant cerebellar ataxia type I (ophtalmoplegia, optic atrophy, dementia, extrapyramidal signs, amyotrophy)

  • spinocerebellar ataxia 1 (SCA1)
  • spinocerebellar ataxia 2 (SCA2)
  • spinocerebellar ataxia 3 (SCA3)/Machado-Joseph disease (MJD)
  • spinocerebellar ataxia 4 (SCA4)
  • spinocerebellar ataxia 12 (SCA12)

- autosomal dominant cerebellar ataxia type II (ophtalmoplegia, dementia, extrapyramidal signs)

  • spinocerebellar ataxia 7 (SCA7) with progressive macular dystrophy (MIM.164500) (expanded trinucleotide repeat in the gene ATXN7 encoding ataxin-7 MIM. 607640).

- autosomal dominant cerebellar ataxia type III (pure cerebellar syndrome)

  • spinocerebellar ataxia 5 (SCA5)
  • spinocerebellar ataxia 6 (SCA6)
  • spinocerebellar ataxia 8 (SCA8)
  • spinocerebellar ataxia 11 (SCA11)

- ataxia and epilepsy

  • spinocerebellar ataxia 10 (SCA10)
  • spinocerebellar ataxia 17 (SCA17) (TBP TATA box-binding protein MIM.600075)