Etiolohy
germline gain-of-function mutation of KCNQ1, an alpha subunit of potassium channels
germline gain-of-function mutation of KCNE2, the beta subunit of the KCNQ1-KCNE2 channel responsible for a background potassium current
References
Otway R, Vandenberg JI, Fatkin D. Atrial fibrillation—a new cardiac channelopathy. Heart Lung Circ. 2007 Oct;16(5):356-60. PMID: 17768091