asthma
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Asthma is a chronic respiratory condition that affects children and adults. Genetic predisposition and environmental factors interact to produce the disease.
Types
Synopsis
mucus plugs
mucosal eosinophilic infiltrate
mucosal basement membrane thickening with sunmembranous collagen deposition
distinctive inclusions in airway mucus
- Charcot-Leyden crystals
- creola bodies
- Curschmann spirals
epithelial shedding (desquamation)
goblet cell metaplasia (goblet cell hyperplasia)
squamous metaplasia
airway wall edema
bronchial mucus gland hyperplasia
airway smooth muscle hyperplasia
Susceptibility
ORMDL3 at 17q21 (17611496)
IL12B at 5q31-33 (15322986)
6p21
IL13 (TH2 cytokine signaling pathway)
ADAM33
DPP10 (peptidase gene)
PHF11 at 13q14
Locus AS1 : 14q24 (12119603)
Tim1 (mouse)
C5
Videos
Asthma by Washington Deceit
References
Moffatt MF, Kabesch M, Liang L, Dixon AL, Strachan D, Heath S, Depner M, von Berg A, Bufe A, Rietschel E, Heinzmann A, Simma B, Frischer T, Willis-Owen SA, Wong KC, Illig T, Vogelberg C, Weiland SK, von Mutius E, Abecasis GR, Farrall M, Gut IG, Lathrop GM, Cookson WO. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature. 2007 Jul 4; PMID: 17611496
Reviews
Makinde T, Murphy RF, Agrawal DK. Immunomodulatory role of vascular endothelial growth factor and angiopoietin-1 in airway remodeling. Curr Mol Med. 2006 Dec;6(8):831-41. PMID: 17168735
Barnes PJ. New therapies for asthma. Trends Mol Med. 2006 Nov;12(11):515-20. PMID: 17011826
Kay AB. The role of eosinophils in the pathogenesis of asthma. Trends Mol Med. 2005 Apr;11(4):148-52. PMID: 15823751
Wills-Karp M, Ewart SL. Time to draw breath: asthma-susceptibility genes are identified. Nat Rev Genet. 2004 May;5(5):376-87. PMID: 15143320
Weiss ST, Raby BA. Asthma genetics 2003. Hum Mol Genet. 2004 Apr 1;13 Spec No 1:R83-9. PMID: 14764626
Cookson W. A new gene for asthma: would you ADAM and Eve it? Trends Genet. 2003 Apr;19(4):169-72. PMID: 12683965
Cookson WO, Moffatt MF. Genetics of asthma and allergic disease. Hum Mol Genet. 2000 Oct;9(16):2359-64. PMID: 11005790